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N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride

Erlotinib hydrochloride

CAS: 183319-69-9

Molecular Formula: C22H24ClN3O4

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N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride - Names and Identifiers

Name Erlotinib hydrochloride
Synonyms ERLOTINIB HCL
Erlotinib HCl
Erlotinib, OS-774
ERLOTINIB HCL SALT
Erlotinib hydrochloride
Erlotinib, Hydrochloride Salt
Tarceva HydrochlorideSee E625000
Tarceva Hydrochloride See E625000
quinazolinamine, Hydrochloride Salt, OSI 774, Tarceva
N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4- Hydrochloride
N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
N-(3-Ethynylphenyl)-6,7-bis-(2-methoxyethoxy)-quinazolin-4-amine
[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4yl]-(3-ethynyl-phenyl)-amine
6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochloride
N-(3-Ethynylphenyl)-6,7-bis-(2-methoxyethoxy)-quinazolin-4-amine Hydrochloride
N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride
N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, Hydrochloride Salt, OSI 774, Tarceva
N-(2-chloro-6-methyl-phenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methyl-pyrimidin-4-yl]amino]thiazole-5-carboxamide
CAS 183319-69-9
EINECS 620-491-0
InChI InChI=1/C22H23N3O4.ClH/c1-4-16-5-7-17(8-6-16)25-22-18-13-20(28-11-9-26-2)21(29-12-10-27-3)14-19(18)23-15-24-22;/h1,5-8,13-15H,9-12H2,2-3H3,(H,23,24,25);1H

N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride - Physico-chemical Properties

Molecular FormulaC22H24ClN3O4
Molar Mass429.9
Melting Point223-225°C
Boling Point548.2°C at 760 mmHg
Flash Point285.4°C
Solubility Soluble in DMSO (3 mg/ml), methanol (sparingly), water (<1 mg/ml), and ethanol (<1 mg/m
Vapor Presure4.52E-12mmHg at 25°C
AppearanceYellow powder.
ColorWhite or off-white
pKapKa (25°): 5.42
Storage ConditionInert atmosphere,Store in freezer, under -20°C
StabilityStable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
UseHER-1 / EGFR tyrosine kinase inhibitor
In vitro studyErlotinib acts on HNS human head and neck tumor cells and effectively inhibits EGFR autophosphorylation. HNS human head and neck tumor cells are cell lines that express high levels of EGFR. Erlotinib had no effect on SBC-5 cell proliferation. In contrast, Erlotinib significantly inhibited PC-9 cell proliferation in a dose-dependent manner, with PC-9 cells containing a deletion mutation in exon 19 of the EGFR gene. Erlotinib treatment also did not affect SBC-5 cell migration. Erlotinib inhibited HPAC and Capan-1 cell growth with IC50 of 1.1 and 3 µm, respectively. 10 uM Erlotinib inhibits EGFR phosphorylation at Y845 (Src-dependent phosphorylation) and Y1068 (autophosphorylation) sites. Erlotinib inhibits extracellular signal-regulated kinases, Akt, and S6 only in the most sensitive cell lines.
In vivo studyErlotinib alone inhibits tumor growth in the H460a tumor model in a dose-dependent manner and is related to circulating levels of the drug.

N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride - Risk and Safety

Safety Description24/25 - Avoid contact with skin and eyes.
HS Code29335990
N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride
Supplier List
Nantong Reform Petro-Chemical CO., LTD.
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CAS: 183319-69-9
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Hefei TNJ Chemical Industry Co.,Ltd.
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CAS: 183319-69-9
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Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Erlotinib HCl (OSI-744) Visit Supplier Webpage Request for quotation
CAS: 183319-69-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: Erlotinib hydrochloride Request for quotation
CAS: 183319-69-9
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: Erlotinib hydrochloride Request for quotation
CAS: 183319-69-9
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: Erlotinib Visit Supplier Webpage Request for quotation
CAS: 183319-69-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: Erlotinib hydrochloride Request for quotation
CAS: 183319-69-9
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Shanghai Yuanye Bio-Technology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: Erlotinib HCl (OSI-744) Visit Supplier Webpage Request for quotation
CAS: 183319-69-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride
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